22
Feb

Weekly Tweets for 2010-02-22

  • I don't need a friend who changes when I change and who nods when I nod; my shadow does that much better. http://bit.ly/7KBCIE @googlebooks #
  • #lung Lisa Coussens was convinced by David to study lung cancer. She focused on solid tumor. Next, Julien Sage, small cell lung carcinoma... #
  • #lung He made a joke on NEJM, one case one report, he is thinking about submiting his paper again by deleting other 70s patiets data. NSCLC #
  • #lung Wnt signaling links to almost everything. Through human samples, David found things - steal ideas from breast cancer studies - Wnt3a #
  • #lung David Jablons pointed out that death caused by one state of lung cancer = 4 other cances. Move the science forward; need it to fight #
  • No Evidence for Clonal Selection due to Lentiviral Integration Sites in hiPSCs; http://bit.ly/aYiLsr (via @iPSCellNews) I saw this too, nice #
  • #lung Mark just finished his talk. Again, exciting! New Cre driver, new brainbow, clonal analysis, genome signal/receptor profile, ... KING! #
  • #lung agarose into the lung, vibratone, O2 supplied media: viability and motility is good, no ingress/egress. Very nice: zoom-in, rotate, go #
  • #lung Max Krummel talks about realtime imaging of immune responses in lung. System biology, learn the system from observing. 2-photon, video #
  • #lung Tushar Desai on aveolar epithelium. Lysozyme-Cre with mTmG, fate mapping. Next, Dean Sheppard on aV-Integrins during lung injury. #
  • #lung Tom Kornberg talks about why fly? Hox genes as the start. Genes are conserved. Fly dorsal air sacs, lung? Fliopodia responses to Dpp #
  • #lung Allometric scaling of shape vs division angle. My q: it is based on a cyclinder model, but real tube is not cyclinder, zones of angles #
  • #lung Describe a tube, surface area and shape factor. Simple model suggests a exponentially shape change. In continuous model, angle divides #
  • #lung Wallace Marshall continues Sprouty story, mainly about division principles during lung patterning. Modeling. Start with PKD #
  • #lung They are maing a lung without vascular, white lung! Poor mice died immediately after birth. Vegf-A KO study, epithelia HGF decreases #
  • #lung Response to Mark's question, Sprouty is needed for the non-unifom signaling. They haven't show that Fgf sets the non-uniform pattern #
  • #lung Take-home, Erk1/2 could regulate the cell division orientation! Division then regulates branching pattern. Next, Thiennu Vu, vasculatu #
  • #lung Turn on Kras phenocopy the Spry1/2DKO! Not proliferation. Oriented cell division is the reason. Very labor intense analysis process #
  • #lung single Spry KO shows a little gain-of-function in places. Nan did Spry1 and Spry2 double KO, lose, instead of gain. Less Fgf resumes #
  • #lung Mark's lab discovered Sprouty in fly and she studied it in mice. Sprouty, inhibits FGF signaling, induced by RTK, can antagonize RTK #
  • #lung Gail Martin is up. MAPK signaling, cell division in sprouty mutant. She started with FGF signaling in chick and mouse development #
  • #lung screen branching defects: sprouty2-/- loses specific branch domain; a mutant shifts the branch location; mutants have altered artery #
  • #lung Three branching modes used many times to generate the complex structure between E12-E15 during mouse dev. Fix seq of these subroutines #
  • Sitting in Diller, the Bay Area Workshop on Lung Development, Physiology and Cancer is starting. Ross Metzger starts with the branching ... #
  • http://twitpic.com/144pwj - It's a great day for alpine skiing - enjoy today's Olympic doodle. (via @google) I am going this Sunday! HitTree #
  • In science "fact" can only mean confirmed to such a degree that it would be perverse to withhold provisional assent. RT http://bit.ly/62dMW1 #
  • Don't simply retire from something; have something to retire to. http://bit.ly/8PCYUu (via @googlebooks) Exactly! Pursue an active life! in reply to googlebooks #
  • Obesity. With an interactive game and two fascinating health education films from the 60s and 70s http://bit.ly/aAatl8 via @ExploreWellcome #
  • Some painters transform the sun into a yellow spot, others transform a yellow spot into the sun. http://bit.ly/71s591 (via @googlebooks) U? #
  • It is hot here! They said that the summer is coming. OMG. Image a place where it is hot, but within 4-hr driving mountains are full of snow! #
  • Research is what I'm doing when I don't know what I'm doing. http://bit.ly/5Pt5Mw (via @googlebooks) My take: research is what I love to do #
  • 《纽约时报》说美国《时代》周刊前任执行主编 Walter Isaacson 得到了乔布斯授权撰写他的自传，乔布斯本人也会参与。Isaacson 之前写过富兰克林和爱因斯坦的自传，都是畅销书。http://tr.im/On9d (via #
  • In a very terrible hangover state, having difficult to debug my script. Any tips/tricks/solutions to cure it quickly? Very appreciated $&$& #
  • The secret superpowers in all of us: science and Heroes in the Metro today: http://bit.ly/aSGGBj (via @wellcometrust) We are all heroes! #
  • Parents, indeed the toughest job on earth... (via @JoiChua) #
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